In this heart surgery, the surgeon uses stitches to close the PFO . Patent foramen ovale closure is a procedure to close a hole in the heart.We use minimally invasive approaches to treat PFO without open-chest surgery. A PFO closure fills an opening between your heart's two upper chambers. PFO closure is a minimally invasive catheter procedure in which a small device is implanted via a catheter inserted into a large vein in the groin. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs.