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Nevertheless, ODT's have some disadvantages like limited tablet weight, short disintegration time, high cost, and packaging problems. Orally disintegrating tablets may be evaluated as a first option for pediatric and geriatric patients who have swallowing problem.

Criteria for Fast dissolving Drug Delivery System: The tablets should ➢ Not require water to swallow, but it should dissolve or disintegrate in the mouth in matter of seconds. ➢ Be compatible with taste masking. ➢ Be portable without fragility concern. ➢ Have a pleasant mouth feel.

Fast disintegrating tablets (FDTs) are meant for administration to the patients who cannot swallow, such as the elderly, stroke victims, bedridden patients, patients affected by renal failure, and patients who refuse to swallow, such as pediatric, geriatric, and psychiatric patients.

The major disadvantages of FDTs is related to the mechanical strength of tablets. FDT are very porous and soft molded metrics or compressed in a tablet with low compression, which makes tablet friable and brittle which difficult to handle.

The fast disintegration of ODTs is just as much an advantage as it is a disadvantage. Since the medication is absorbed so quickly in the oral cavity, ODTs cannot support controlled or extended-release medication.

High dosage, highly water soluble, poorly compressible and hygroscopic drugs represent the greatest difficulty in a dispersible compressible formulation. The excipients must be carefully selected to produce an array of tablets with high compressibility and low aqueous solubility and hygroscopicity.

Mouth fast dissolving tablets of Cetirizine Hydrochloride were prepared by direct compression method using sodium starch glycolate, croscarmellose and crospovidone as superdisintegrants in different concentrations and Pearlitol as directly compressible diluent.

Novel technologies with improved performance, patient compliance, and enhanced quality have emerged in the recent past. The fast dissolving drug delivery system started gaining popularity and acceptance as a new drug delivery system because they are easy to administer and lead to better patient compliance.