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Istry regiochemistry rate expression Nu quality LG quality preferred solvent? substrate 1 SN2 and E2 one step this single step is the rate-determining step (RDS) SN2: steric hindrance blocking Nu (Nu is in RDS) E2: blocking B isn t a big obstacle (B doesn t join substrate) SN2: inversion (backside attack, since LG blocks frontside) E2: cis vs. trans determined by anti-periplanar transition-state E2: possible products from deprotonation of any -carbon major product w/ bulky base: less s.

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