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Get Scffbxl3 Controls The Oscillation Of The Circadian Clock By Directing The Degradation Of

That of native tissue, we detected a significant delay in Cry2 degradation in cells transfected with Fbxl3Afh. These data provide a role for Fbxl3 in modulating mammalian circadian homeostasis and a biological mechanism whereby this can occur. Fbxl3Afh lengthens tDD by 3 hours, delaying the rate of Cry protein degradation and prolonging the phase of Cry-mediated negative feedback. As a consequence, peak levels of Per, Cry, and Bmal1 mRNA are reduced in homozygotes, as are the corresponding prot.

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