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0 1000 100 10 1 0 200 400 600 800 Time (h) DutaMab structure in IgG1 format IgG or Fab of any isotype possible DutaMabs can be discovered and optimized in a rapid, reliable process o o o Equivalent to state-of-the-art monospecific Mabs Standard phage display and high-throughput screening methods Discovery process proven using several pairs of drug targets DutaMabs are a completely modular system, i.e. affinities are fully retained when the two monospecific Fab se.

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