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noun. 1. a sheet of paper folded once to make two leaves, or four pages, of a book or manuscript. 2. a volume having pages of the largest size, formerly made from such a sheet.

folio in American English a. a large sheet of paper folded once, so that it forms two leaves, or four pages, of a book, manuscript, etc.

folios. A large sheet of paper folded once, so that it forms two leaves, or four pages, of a book, manuscript, etc. Webster's New World. Similar definitions. A large size of book, about 12 by 15 inches, made of sheets folded in this way.

The term folio derives from the Latin word “folium” (leaf) and refers to a traditional book format in which the size of the page is determined by the fact that the sheets used in the production of the book are folded only once. An unfolded sheet is called an atlas format, double folio or large folio.

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A folio number is a unique identifier used to keep track of investments or pieces of property. Lawyers, bank creditors, and investors will often all use folio numbers in their businesses. Mutual funds use folio numbers to identify account holders in their investment pool.

noun A book or other publication, or a blank book, etc., consisting of sheets or of a single sheet folded once. noun The size of such a book, etc.: as, an edition of a work in folio.