Get Skin Substitute Application

1. Collagen–Chondroitin 6-Sulfate. A summary of recent studies in which collagen was used as the base material for skin tissue engineering scaffolds is shown in Table 1. Freeze-drying is the major methods for making collagen skin substitutes, likely due to the low-cost, wide availability and simplicity of this method.

The most widely used biological substitute worldwide are cadaveric skin allograft, porcine skin xenograft and amnion.

Skin substitute graft procedures include the application of non-autologous human skin (dermal or epidermal, cellular and acellular) grafts (e.g., homograft, allograft), non-human skin substitute grafts (i.e., xenograft), and biological products that form a sheet scaffolding for skin growth.

One of the most widely used temporary skin substitutes is frozen cadaver skin. This allograft skin will heal and be incorporated into the patient's tissues when applied to a raw or otherwise prepared burn surface.

ing to Medicare billing guidelines for skin substitutes, if a product is deemed medically necessary, it will be included in one of the other regular management procedures and will not be charged separately.

The Current Procedural Terminology (CPT) application CPT codes 15271-15278 intended for the use of skin substitutes is entitled “Skin Substitute Grafts”.

Skin substitutes are a heterogeneous group of biologic, synthetic, or biosynthetic materials that can provide temporary or permanent coverage of open skin wounds. Skin substitutes ideally possess the composition and function of skin or have the potential for autologous regenerative healing when applied to a wound [2].