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The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis: Titrate oxygen to a saturation target of 94% Take blood cultures and consider source control. Administer empiric intravenous antibiotics.

What is the Sepsis Six Care bundle? The UK Sepsis Trust developed the 'Sepsis Six' – a set of six tasks including oxygen, cultures, antibiotics, fluids, lactate measurement and urine output monitoring- to be instituted within one hour by non-specialist practitioners at the frontline.

Shock can be divided into two specific phases. The first is WARM SHOCK which occurs early, is compensated, and is hyperdynamic. The second is COLD SHOCK which occurs late and is uncompensated with decreased cardiac output.

Early identification, resuscitation, initiation of antibiotics and prompt identification and management of the underlying source and cause of sepsis is imperative in improving patient outcomes.

Diagnosis of shock (septic or otherwise) per WHO criteria requires the presence of all three of the following: cold extremities, prolonged capillary refill >3 seconds, and weak/fast pulse. Measurement of blood pressure is not required.

The mnemonic “SEPSIS” (S = Slurred speech or confusion, E = Extreme shivering or muscle pain, fever, P = Passing no urine all day, S = Severe breathlessness, I = It feels like you are going to die, S = Skin mottled or discolored) has been developed by the World Sepsis Day committee, so as to raise public awareness of ...

TIME stands for Temperature, Infection, Mental decline and Extremely ill. These are not the only signs and symptoms of sepsis, of course, but these are the most common symptoms that people are able to recognize.