Get Vu Application 2.doc. Nature 469, 415 (2011). Doi10.1038/nature09637 - Mc Vanderbilt

Conclusions: This is the first study to demonstrate that pIgR and IgA are colocalized in the secretory granules of human Paneth cells. These findings suggest that, in addition to their well-recognized role in innate immunity, Paneth cells are involved in IgA-mediated acquired immunity in the gastrointestinal tract.

The villi are composed of terminally differentiated cells, including absorptive enterocytes, goblet cells, and enteroendocrine cells, whereas the crypt contains stem and transit amplifying cells. Morphogenesis and Compartmentalization of the Intestinal Crypt National Institutes of Health (NIH) (.gov) https://.ncbi.nlm.nih.gov › articles › PMC5987226 National Institutes of Health (NIH) (.gov) https://.ncbi.nlm.nih.gov › articles › PMC5987226

Conclusions: This is the first study to demonstrate that pIgR and IgA are colocalized in the secretory granules of human Paneth cells. These findings suggest that, in addition to their well-recognized role in innate immunity, Paneth cells are involved in IgA-mediated acquired immunity in the gastrointestinal tract.

The expression of Lgr5 has been demonstrated in a variety of epithelial tissues including mammary glands and hair follicle and represent presumptive stem cells in these adult tissues.

The villi are composed of terminally differentiated cells, including absorptive enterocytes, goblet cells, and enteroendocrine cells, whereas the crypt contains stem and transit amplifying cells. Morphogenesis and Compartmentalization of the Intestinal Crypt National Institutes of Health (NIH) (.gov) https://.ncbi.nlm.nih.gov › articles › PMC5987226 National Institutes of Health (NIH) (.gov) https://.ncbi.nlm.nih.gov › articles › PMC5987226

The crypt is a contiguous pocket of epithelial cells at the base of the villus, in which intestinal stem cells (ISCs) are periodically activated to produce progenitor or transit amplifying (TA) cells which are committed to produce mature cell lineages [43,44,45].

The expression of Lgr5 has been demonstrated in a variety of epithelial tissues including mammary glands and hair follicle and represent presumptive stem cells in these adult tissues.

Coupled with organoid cultures in vitro, their data implied that Paneth cells may elaborate Wnt ligands to activate Wnt signaling in receptor-expressing Lgr5+ CBCs.

The crypt is a contiguous pocket of epithelial cells at the base of the villus, in which intestinal stem cells (ISCs) are periodically activated to produce progenitor or transit amplifying (TA) cells which are committed to produce mature cell lineages [43,44,45].

Crypts are intestinal glands which can be described as invaginations between the villi. The mucous provides protection against chemical damage from enzymes and mechanical damage caused by friction as chyme moves through the lumen. The enterocytes are involved in both digestion and absorption. Intestinal Gland – Knowledge and References - Taylor & Francis taylorandfrancis.com https://taylorandfrancis.com › gastroenterology › intestin... taylorandfrancis.com https://taylorandfrancis.com › gastroenterology › intestin...

Coupled with organoid cultures in vitro, their data implied that Paneth cells may elaborate Wnt ligands to activate Wnt signaling in receptor-expressing Lgr5+ CBCs.

The intestinal crypt is a sterile invagination composed of goblet, stem, and Paneth cells, which can secrete mucus and antimicrobial peptides such as cryptdins. Intestinal Crypts - an overview | ScienceDirect Topics ScienceDirect.com https://.sciencedirect.com › topics › intestinal-crypts ScienceDirect.com https://.sciencedirect.com › topics › intestinal-crypts

Crypts are intestinal glands which can be described as invaginations between the villi. The mucous provides protection against chemical damage from enzymes and mechanical damage caused by friction as chyme moves through the lumen. The enterocytes are involved in both digestion and absorption. Intestinal Gland – Knowledge and References - Taylor & Francis taylorandfrancis.com https://taylorandfrancis.com › gastroenterology › intestin... taylorandfrancis.com https://taylorandfrancis.com › gastroenterology › intestin...

Colonic deep crypt secretory (DCS) cells are a specialized, organ-specific cell population located at the base of the colonic crypt. They are critical for the regenerative capacity of the colonic epithelium and share some similarities to Paneth and goblet cells in the small intestine. Deep Crypt Secretory Cell Differentiation in the Colonic ... - NCBI nih.gov https://.ncbi.nlm.nih.gov › articles › PMC9982040 nih.gov https://.ncbi.nlm.nih.gov › articles › PMC9982040

The intestinal crypt is a sterile invagination composed of goblet, stem, and Paneth cells, which can secrete mucus and antimicrobial peptides such as cryptdins. Intestinal Crypts - an overview | ScienceDirect Topics ScienceDirect.com https://.sciencedirect.com › topics › intestinal-crypts ScienceDirect.com https://.sciencedirect.com › topics › intestinal-crypts

Defensin alpha 6 (DEFA6) and guanylate cyclase activator 2A (GUCA2A) are selective protein markers of Paneth cells.

Colonic deep crypt secretory (DCS) cells are a specialized, organ-specific cell population located at the base of the colonic crypt. They are critical for the regenerative capacity of the colonic epithelium and share some similarities to Paneth and goblet cells in the small intestine. Deep Crypt Secretory Cell Differentiation in the Colonic ... - NCBI nih.gov https://.ncbi.nlm.nih.gov › articles › PMC9982040 nih.gov https://.ncbi.nlm.nih.gov › articles › PMC9982040

Paneth cells are specialized intestinal epithelial cells that secrete abundant antimicrobial proteins, including lysozyme, and thus disrupting Paneth cell secretion can lead to inflammatory disease (2–4).

Defensin alpha 6 (DEFA6) and guanylate cyclase activator 2A (GUCA2A) are selective protein markers of Paneth cells.

The G protein-coupled receptor Lgr5 and the Polycomb group protein Bmi1 are two recently described molecular markers of self-renewing and multipotent adult stem cell populations residing in the crypt of the small intestine, capable of supporting regeneration of the intestinal epithelium (1, 2).

Paneth cells are specialized intestinal epithelial cells that secrete abundant antimicrobial proteins, including lysozyme, and thus disrupting Paneth cell secretion can lead to inflammatory disease (2–4).

The G protein-coupled receptor Lgr5 and the Polycomb group protein Bmi1 are two recently described molecular markers of self-renewing and multipotent adult stem cell populations residing in the crypt of the small intestine, capable of supporting regeneration of the intestinal epithelium (1, 2).