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Ess has been made in our understanding of how cells establish polarity during asymmetric cell division and how determinants, in the form of localized proteins and mRNAs, are segregated. In particular, genetic studies in Drosophila and Caenorhabditis elegans have linked cell polarity, G protein signaling and regulation of the cytoskeleton to coordination of mitotic spindle orientation and localization of determinants. Also, several new studies have furthered our understanding of how asymmetricall.
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GAI FAQ
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Asymmetric cell division is a fundamental mechanism that generates cell diversity while maintaining self-renewing stem cell populations in multicellular organisms. Both intrinsic and extrinsic mechanisms underpin symmetry breaking and differential daughter cell fate determination in animals and plants.
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Cell division in plants is particularly important as cells cannot rearrange. It therefore determines the arrangement of cells (topology) and their size and shape (geometry).
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In stem cells and progenitors Asymmetric divisions of these embryonic cells gives rise to one cell of the same potency (self-renewal), and another that maybe of the same potency or stimulated to further differentiate into specialized cell types such as neurons. Asymmetric cell division - Wikipedia wikipedia.org https://en.wikipedia.org › wiki › Asymmetric_cell_division wikipedia.org https://en.wikipedia.org › wiki › Asymmetric_cell_division
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T cell can divide asymmetrically after the activation by APC showing unequal distribution of various proteins between proximal and distal daughters. Proximal and distal daughters are prone to become effector and memory T cells respectively. APC, antigen-presenting cell.
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During this process, asymmetric division of the zygote is essential for normal embryogenesis and seed formation. Successful asymmetric zygote division requires the mechanism that ensures both accurate position and correct orientation of cell division plane.
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ACDs in the embryogenesis After fertilization, the asymmetric division of a longitudinally expanded zygote generates a smaller apical cell and a larger basal cell with distinct cell fates. The apical cell divides and develops into the majority of the proembryo.
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In the asymmetric division model, a stem cell produces one differentiated cell and one stem cell. In the symmetric division model, a stem cell produces two differentiated cells or two stem cells. Uncovering division patterns of stem cells has been subject of intense research in the last fifteen years.
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The localization of the mitotic apparatus in polarized cells results in unequal cell division, which plays an important role during development and differentiation. Polar body formation is one of the most remarkable examples of unequal division.
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Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed mechanistic understanding of ACD is therefore necessary to understand cell fate decisions in health and disease.
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Keywords relevant to Asymmetric Cell Division
- jan
- mitotic
- Par-3
- planar
- neuroblasts
- Par-6
- GAI
- apicalbasal
- Miranda
- neuralized
- 2003
- localization
- elegans
- Asymmetrically
- biol
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