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D. Mild cognitive impairment (MCI) is a general term most commonly used to describe a subtle but measurable memory disorder by the Alzheimer s association. According to this definition, a person with MCI is in a state between normal aging and dementia in which cognitive defects are present but function is preserved. Amnestic MCI refers to the subtype that has a principal memory element, either alone or in combination with other cognitive-domain impairments. Approximately 80 percent of patient.
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Intention-to-treat analysis is a method for analyzing results in a prospective randomized study where all participants who are randomized are included in the statistical analysis and analyzed ing to the group they were originally assigned, regardless of what treatment (if any) they received.
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Intention-to-treat analysis is a comparison of the treatment groups that includes all patients as originally allocated after randomization. This is the recommended method in superiority trials to avoid any bias.
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Intention-to-treat (ITT) analysis refers to analysis based on the initial treatment assignment, and not on the treatment eventually received. This type of analysis, now widely accepted as standard for the analysis of clinical trials, provides an unbiased comparison across the treatment groups.
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Intention to treat analyses are done to avoid the effects of crossover and dropout, which may break the random assignment to the treatment groups in a study. ITT analysis provides information about the potential effects of treatment policy rather than on the potential effects of specific treatment.
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Intention-to-treat analysis (ITT) is a “catch-all” measure that includes all randomized patients, regardless of their adherence with the entry criteria, regardless of treatment or lack of treatment received, and regardless of their withdrawal from the treatment or protocol deviation.
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The ITT estimate is essentially the difference between the treatment group and control group mean (often adjusted for baseline differences), regardless of the degree of compliance.
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Intention-to-treat analysis A method of analysis for randomized trials in which all patients randomly assigned to one of the treatments are analyzed together, regardless of whether they completed or received that treatment, to preserve randomization.
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The Intention-to-Treat Principle How to Assess the True Effect of Choosing a Medical Treatment. The intention-to-treat (ITT) principle is a cornerstone in the interpretation of randomized clinical trials (RCTs) conducted with the goal of influencing the selection of medical therapy for well-defined groups of patients.
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