How do I treat motion sickness symptoms? If you're already feeling sick, take a Dramamine to soothe the effects of motion sickness.Keep your eyes on the horizon. We treat hundreds of people with vertigo and balance disorders each year. We're experts in creating effective management plans that meet your health goals. Dimenhydrinate: An over-the-counter antihistamine that helps with motion sickness. If you have a history of severe motion sickness talk to your healthcare provider about medications you can use to prevent motion sickness. Focus on the horizon or on a distant, stationary object. Motion sickness is a normal response to complex motion stimuli of sufficient intensity and duration that is thought to be due to a mismatch of signals. Promethazine. Promethazine is a prescription antihistamine drug used to treat motion sickness.