The right of the people to be secure in their persons, houses, papers, and effects, against unreasonable searches and seizures, shall not be violated. The 4 th Amendment to the US Constitution guarantees freedom from unreasonable search and seizure.AMENDMENT 4—SEARCHES AND SEIZURES have been reaffirmed directly in a Fourth Amendment case. The Fourth Amendment prohibits the United States government from conducting "unreasonable searches and seizures. In general, most warrantless searches of private premises are prohibited under the Fourth Amendment, unless a specific exception applies. Second, the Fourth Amendment acts as a powerful barrier against unreasonable searches and seizures. In general, most warrantless searches of private premises are prohibited under the Fourth Amendment, unless a specific exception applies. The Fourth Amendment to the U.S. Constitution protects individuals from unreasonable searches and seizures. The Fourth Amendment to the United States Constitution prohibits the federal government from conducting unreasonable searches and seizures. The Fourth Amendment protects individuals against unreasonable searches and seizures.