Patent foramen ovale closure; Vascular surgery and endovascular intervention; Varicose vein therapies; Fistula Access. Most people with a patent foramen ovale don't need treatment.PFO often has no symptoms. Many people don't need treatment unless they're at risk of stroke or blood clots. Patent foramen ovale closure can help reduce risk of another ischemic stroke. Learn more about a minimally-invasive treatment option. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. Patent foramen transcatheter repair is a procedure to fix this hole in the heart. Normally, the atrial septum separates the right and left atria.