Learn more about the causes and complications of this condition in which a hole in the heart doesn't close the way it should after birth. The healthcare provider inserts the catheter through a blood vessel in the groin and guides it to the PFO.Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. Most people with a patent foramen ovale don't need treatment. PFO treatment closes the Patent Foramen Ovale (PFO) through blood thinning medicines or a catheter-based procedure to close the hole.