Our team of interventional cardiologists specializes in a minimally invasive PFO closure procedures. Patent foramen ovale (PFO).Similar to an ASD, a patent foramen ovale is a type of hole in the septal tissue that separates the upper chambers of the heart. Northwestern Medicine Neuroscience programs provide treatment for a full range of potential neurological concerns, including patent foramen ovale. A new technology that enables specially trained physicians to use a single stitch to close an opening between the upper chambers of the heart. The foramen ovale is a small hole in the fetal heart, located between the right and left atria (upper chambers). However, it may cause serious complications under certain circumstances. Treatment is a catheter procedure or surgery to close the opening in the heart. Treatment includes a catheter procedure or surgery to close the opening in the heart. If you have a PFO and low blood oxygen levels or an unexplained stroke, you may need a procedure to close the hole.