Possible PFO symptoms include: Stroke. This may include bleeding or signs of infection in the area where they put the catheter.Additional Common Questions. A patent foramen ovale is a small, flaplike opening in the wall between the upper chambers of the heart. Infants with a PFO and no other heart defects do not have symptoms. What are the symptoms of PFO? Some adults with PFOs also suffer from migraine headaches. PFO are often undiagnosed as there are no obvious signs and symptoms or complications with an undiagnosed PFO. These include sudden weakness or numbness, confusion, difficulty seeing out of an eye, or loss of coordination. Key points about patent foramen ovale.