PFO closure is a minimally invasive procedure that involves a small incision in the groin area. A patent foramen ovale or PFO is a defect in the wall between the two upper chambers of the heart.A transcatheter intervention is the most common way to close a PFO. Patent Foramen Ovale (PFO) closure is a procedure used to seal a small hole between the upper chambers of the heart that fails to close naturally after birth. This review discusses results of these studies, evaluation strategies for PFO and PFO closure, and additional indications for PFO closure. The first in the world to use a new occlusion system to treat patients with patent foramen ovale (PFO) who are at risk of recurrent ischemic stroke. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery.