Patent foramen ovale (PFO) closure involves closing a small tunneled hole in the heart that has been linked to an increased risk of stroke. If you need treatment, a highly trained heart expert at RUSH will likely close the PFO using a procedure called cardiac catheterization.Our team of interventional cardiologists specializes in a minimally invasive PFO closure procedures. We treat patent foramen ovale using a minimally-invasive cardiology procedure known as a cardiac catheterization. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. One way to treat an atrial septal defect is to use a catheter. The technique for percutaneous patent foramen ovale (PFO) closure has dramatically evolved during the past decade. Learn more about the causes and complications of this condition in which a hole in the heart doesn't close the way it should after birth. , Chicago, IL, USA).