A PFO closure fills an opening between your heart's two upper chambers. If you have a PFO and low blood oxygen levels or an unexplained stroke, you may need a procedure to close the hole.The medical term for this opening in the heart is a patent foramen ovale. (PFO). Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. A PFO closure uses a medical device to close an opening between your heart's two upper chambers. You only need this opening as a fetus. Patent foramen transcatheter repair is a procedure to fix this hole in the heart. Normally, the atrial septum separates the right and left atria. PFOs, on the other hand, are normal before birth but may fail to close after birth.