PFO treatment closes the Patent Foramen Ovale (PFO) through blood thinning medicines or a catheter-based procedure to close the hole. PFO closure may be achieved through open heart surgery or through a transcatheter procedure using an occlusion device.The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. However, it may cause serious complications under certain circumstances.