PFO closure may be achieved through open heart surgery or through a transcatheter procedure using an occlusion device. This guide is for patients who have previously suffered a stroke that was from an unknown cause (also called "cryptogenic stroke").Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. The surgeons at our adult congenital heart center perform patent foramen ovale closures and actively research innovative techniques to treat the condition. A PFO closure fills an opening between your heart's two upper chambers. (Class III; Level of Evidence B). New recommendation.