In this procedure, the provider inserts a thin, flexible tube called a catheter into a blood vessel in the groin area. Patent foramen ovale closure is a procedure to close a hole in the heart.We use minimally invasive approaches to treat PFO without open-chest surgery. If you have a PFO and low blood oxygen levels or an unexplained stroke, you may need a procedure to close the hole. The PFO closure procedure will take place in a heart catheterization laboratory, where minimally invasive procedures are performed.