In this procedure, the provider inserts a thin, flexible tube called a catheter into a blood vessel in the groin area. Learn more about the causes and complications of this condition in which a hole in the heart doesn't close the way it should after birth.PFO closure with the Amplatzer 14,15 or Helex devices appears safe with fluoroscopic guidance only and without routine balloon sizing. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. This document addresses the transcatheter closure of patent foramen ovale and transcatheter or open left atrial appendage (LAA) closure. These presentations and their resolution are discussed in this article. The technique for percutaneous patent foramen ovale (PFO) closure has dramatically evolved during the past decade.