Most people will not have any signs or symptoms directly from PFO at all. Possible PFO symptoms include: Stroke.A patent foramen ovale is a small, flaplike opening in the wall between the upper chambers of the heart. The foramen ovale is a normal opening between the upper two chambers of an unborn baby's heart. The larger the hole, the more likely symptoms are. PFOs, on the other hand, are normal before birth but may fail to close after birth. Most people don't have symptoms. This may include bleeding or signs of infection in the area where they put the catheter. Additional Common Questions. Premier Health offers a full range of heart and vascular care – preventive, diagnostic, nonsurgical, surgical, and rehab – across Southwest Ohio.