Provides outreach and education for independent inventors who file patent applications without the assistance of a registered patent attorney or 101.2 Application, Effective Date and Construction.These Local Patent Rules shall take effect on June 1, 2010 (the "Effective Date"). The purpose of this guide is to provide you with basic information about filing a utility patent application with the USPTO. Mild disc disease from L3 through L5 without significant stenosis. Narrowing in the pulmonary artery makes it hard for blood to reach your child's lungs. An unclosed hole in the main body artery (aorta). Spinal nerves exit the spinal canal through the intervertebral foramen (also called the nerve root canal) to branch out to your body. A neural foramen is an opening where a spinal nerve exits your spine and branches out to other parts of your body. To survive prior before surgery, the blood must mix somewhere in the heart.