PFO treatment closes the Patent Foramen Ovale (PFO) through blood thinning medicines or a catheter-based procedure to close the hole. Most people with a patent foramen ovale don't need treatment.Patent foramen ovale (PFO) is a hole between your heart's upper chambers. A patent foramen ovale occurs when a hole that is always present in a newborn's heart fails to close as it should once the lungs begin to function after birth. Percutaneous closure of a patent foramen ovale (PFO) reduces stroke in appropriately selected patients (1). How is Patent Foramen Ovale Treated?