Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery.Patent foramen ovale (PFO) is a hole between the left and right atria (upper chambers) of the heart. This hole exists in everyone before birth. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. If you are at risk for a stroke or blood clot, your physician may recommend a Patent Foramen Ovale transcatheter closure to repair this hole in the heart. However, it may cause serious complications under certain circumstances. A patent foramen ovale or PFO is a defect in the wall between the two upper chambers of the heart. Patent foramen ovale (PFO) is a hole between the left and right atria (upper chambers) of the heart.