Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery.Patent foramen ovale (PFO) is a hole between the left and right atria (upper chambers) of the heart. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. A patent foramen ovale or PFO is a defect in the wall between the two upper chambers of the heart. However, it may cause serious complications under certain circumstances. Discusses patent foramen ovale, which is an opening in the septum of the heart between the upper right and left chambers. Covers diagnosis and treatment. Patent foramen ovale (PFO) is a hole between the left and right atria (upper chambers) of the heart. This hole exists in everyone before birth.