This guideline addresses the appropriateness of transcatheter closure of patent foramen ovale (PFO). Move a special balloon on a catheter to the area of the hole.Inflate the balloon to measure the size of the hole. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. A patent foramen ovale (PFO) is a hole in the wall between the heart's two upper chambers (atria). Before birth all babies have this opening.