Most people with a patent foramen ovale don't need treatment. Patent foramen ovale (PFO) is a hole between your heart's upper chambers.The healthcare provider inserts the catheter through a blood vessel in the groin and guides it to the PFO. How is Patent Foramen Ovale Treated? The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. Patent foramen ovale (PFO) or hole in the heart, affects millions of people and can cause a stroke. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. Patent foramen transcatheter repair is a procedure to fix this hole in the heart.