Discrimination is the unfair or prejudicial treatment of people and groups based on characteristics such as race, gender, age, or sexual orientation. When someone acts on prejudiced attitudes toward a group of people this is known as discrimination.Prejudice is a common human condition. Prejudice just means prejudgment. Discrimination is the process of making unfair or prejudicial distinctions between people based on the groups, classes, or other categories to which they belong The meaning of DISCRIMINATION is prejudiced or prejudicial outlook, action, or treatment. How to use discrimination in a sentence. Finally, we provide a summary and some conclusions. Defining Discrimination. Overt discrimination has long been part of U.S. history.