Learn how to write a resignational letter if you're quitting for personal reasons. Commence your letter with a formal salutation and a concise introductory paragraph.Please accept this letter as a notice of my resignation. A professional resignation letter most importantly outlines the details of your employment and departure. These top samples of resignation letters for personal reasons can be used as helpful templates when you are looking to resign due to personal circumstances. I have decided to resign due to personal reasons that require my immediate attention. The idea is to relay all the important information concerning your resignation while keeping it short and concise. You may opt to resign for medical reasons, for a better job, or for personal reasons. You could also specify the date, especially if you're leaving on short notice, to avoid confusion.