A response to a resignation letter has to be wellframed and polite, but you also need to be able to convey your disappointment at seeing the employee go. It had been a pleasure working with the company.Learn how to write a response to a resignation letter and use our examples and template to help you write your own. Dear Bill: It is with great regret that I accept your resignation as Assistant to the President, effective September 25, 1987. Dear Henry: IN DIFFERENT circumstances I should have deep regret in consenting to your withdrawal as Secretary of Agriculture. I regretfully have to inform you that, after much thought, I have decided to resign and please accept this letter as a formal notice of my resignation. Here is what a heartfelt resignation letter should include with a sample, as well as an example letter noting regret at leaving. How to Write this Acceptance Letter: Expert Tips and Guidelines. Always accept a resignation with dignity and a positive tone, no matter what the circumstances. I regret to inform you that, after much thought, I have decided to resign.