Nursing resignation letters are formal communications that must include specific information. Use these tips to craft a professional letter.Address line; Statement of resignation; Last day of work; Statement of gratitude; Next steps; Closing and signature. For example, "This letter is to formally give notice that I am resigning my position as a nurse practitioner at Jennings Hospital. We've crafted two formats for your nursing resignation: a written letter and an email. I am writing to inform you of my resignation as a Registered Nurse at St. Joseph's Nursing Center. My last day of work will be January 19, 2022. Don't walk into HR ,and state "I am officially resigning as of today" without reasonable cause or some form of explanation. Don't walk into HR ,and state "I am officially resigning as of today" without reasonable cause or some form of explanation. I regret to inform you that I am resigning from my position as "night shift RN for Nice Hospital".