In this article, we will discuss how to write a resignation letter as a nurse and provide examples and tips. Review these tips about how to write a nursing resignation letter, including the information that needs to be included and sample resignation letters.A nursing resignation letter serves as formal notice to your employer that you're leaving your position. It shows professionalism and courtesy. The complete guide to writing a nursing resignation letter with tips, examples, and templates. Read on to learn how to write a solid resignation letter as a nurse, including helpful examples and tips. Dear Mr. Jershey, It is with regret that I have to resign my position as a nurse practitioner in the cardiac unit at UPMC East immediately. In the body of the letter, immediately state your intention to resign and provide your reasoning, including only positive feelings towards your work experience.