A nursing resignation letter serves as formal notice to your employer that you're leaving your position. It shows professionalism and courtesy.In this article, we will discuss how to write a resignation letter as a nurse and provide examples and tips. I regret to inform you that I am resigning from my position as "night shift RN for Nice Hospital". In the first part, briefly introduce the letter and state the nurse's resignation. Just address a letter stating that you are giving 3 weeks notice and your last date of employment. Dear Mr. Jershey, It is with regret that I have to resign my position as a nurse practitioner in the cardiac unit at UPMC East immediately. I am writing to inform you of my resignation as a Registered Nurse at St. Joseph's Nursing Center. My last day of work will be January 19, 2022. Please accept this letter as formal notification that I am resigning from my position as Registered Nurse with (hospital).