How to write a resignation letter that's effective immediately? How to Write an Immediate Letter of Resignation?Learn how to write an immediate resignation letter with our comprehensive guide, including tips, examples, and a customizable template. To write a good and simple resignation letter, greet your manager formally, then state your intent to resign and the date you'll officially depart. Please be advised that I am resigning my position with immediate effect. Regards,. Medical schools involved in the Consortium will not be eligible to apply.