Review these tips about how to write a nursing resignation letter, including the information that needs to be included and sample resignation letters. A nursing resignation letter serves as formal notice to your employer that you're leaving your position.It shows professionalism and courtesy. In this article, we will discuss how to write a resignation letter as a nurse and provide examples and tips. I regret to inform you that I am resigning from my position as "night shift RN for Nice Hospital". Hospitals as listed below. Here's where the KISS principle applies keep it super simple. I would like to inform you of my intention to resign from (Position Name) at (Company Name), effective two weeks from today, (Current Date). Mention that you were grateful for the opportunity, etc. An online search for tactful resignation letters are out there.