The complete guide to writing a nursing resignation letter with tips, examples, and templates. In this article, we will discuss how to write a resignation letter as a nurse and provide examples and tips.In the first part, briefly introduce the letter and state the nurse's resignation. I am writing to inform you of my resignation as a Registered Nurse at St. Joseph's Nursing Center. My last day of work will be January 19, 2022. Here's where the KISS principle applies keep it super simple. How to write a resignation letter that's effective immediately? Many times it is difficult to resign diplomatically and tactfully. My resignation is effective immediately. I'm writing to inform you of my intent to resign from my position as a staff nurse in the ICU at Johnson County Hospital.