In this article, we will discuss how to write a resignation letter as a nurse and provide examples and tips. The complete guide to writing a nursing resignation letter with tips, examples, and templates.Pick the perfect wording and convey the message best suited for your situation. By crafting a resignation letter that reflects your gratitude, professionalism, and commitment to patient care, you can leave knowing that you left with grace. Nursing resignation letters are formal communications that must include specific information. Use these tips to craft a professional letter. I regret to inform you that I am resigning from my position as "night shift RN for Nice Hospital". Staff who voluntarily terminate must submit a letter of resignation to their immediate supervisor with a copy to Human Resources.