Commence your letter with a formal salutation and a concise introductory paragraph. How to write a resignation letter that's effective immediately?It's time to quit the job, and you're not giving two weeks' notice. Here's how to politely write a resignation letter, effective immediately. Learn how to write a resignation letter (and what not to include) and then use our example letters as a guide. Start with the facts and be direct. Employees who resign from employment should provide a twoweek notice in writing in order to be considered as having resigned in good standing. I need to prioritize my health, so I am resigning immediately. " Expression of gratitude. If you subsequently receive a request for separation information, you may attach a copy of this form (DOL-800) as a part of your response.