How to write a resignation letter that's effective immediately? A resignation letter should typically be submitted at least two weeks in advance, adhering to the notice period of your employment contract.Here is our sample email to resign with immediate effect. Dear (Name), I am resigning from my role as (job) with immediate effect. In this article, we cover everything you need to know about writing a resignation letter without notice and provide an example to get you started. Below is an example of an immediate resignation letter from an employee who needed to leave their position due to severe work-related stress. Learn how to write an immediate resignation letter with our comprehensive guide, including tips, examples, and a customizable template. The first step is to determine whether the facility offers PRN jobs and whether there are enough shifts to cover each nurse's needs.