How to write a resignation letter that's effective immediately? A resignation letter due to health and stress lets you inform your employer about your need to step away because of illness or work pressure.When resigning without notice, your letter should state clearly that the resignation will be effective immediately. If the employer determines that the evidence is not satisfactory, the employer shall notify the employee immediately that the termination will remain in effect. (For example, "I regret to inform you that I will be resigning from my position, effective immediately. The information provided in the FAQs is intended to enhance public access and understanding.