For the most part, a two (2) weeks notice resignation letter should be simple and, more importantly, professional. Your letter of resignation should be short and professional.Write a resignation letter, and give two weeks if possible, not just one. A simple, "Please accept this notice of my resignation from my position…" will work great. The associations I've made during my employment here will truly be memorable for years to come. Write a resignation letter, and give two weeks if possible, not just one. I highly recommend talking to the manager in person.