Resignation letter effective immediately due to toxic environment. What should you say in your resignation letter if you want to resign because of the very bad work environment?22 Answers. Recommended. Use template Download PDF. Sample resignation letter due to toxic work environment. Clearly state your resignation and your last day of work. Be professional and cordial in your tone. Second, you want to express gratitude for the opportunity, no matter how good or bad it was. Seeking advice on what reason to provide my work as to why I am leaving the job. The actual reason is because my manager has been hostile towards me.