Keep your letter short. Your resignation letter should be less than one page.Read on to learn how to write a nursing resignation letter, including tips and templates you can use to step away from your position like a pro. By crafting a resignation letter that reflects your gratitude, professionalism, and commitment to patient care, you can leave knowing that you left with grace. A nursing resignation letter serves as formal notice to your employer that you're leaving your position. It shows professionalism and courtesy. How do I convey that I am grateful for my time on this floor, and at the same time be truthful about the flaws that have caused me to resign? Please accept this letter as formal notification that I am resigning from my position as Registered Nurse with (hospital). State that you're leaving, and provide the date of your last day. Note key details about resignation in the handbook.