The subject of the email should clearly indicate your resignation. An example could include your name and the notice, such as "Ms.The complete guide to writing a nursing resignation letter with tips, examples, and templates. For example, "This letter is to formally give notice that I am resigning my position as a nurse practitioner at Jennings Hospital. In the first part, briefly introduce the letter and state the nurse's resignation. In the body of the letter, immediately state your intention to resign and provide your reasoning, including only positive feelings towards your work experience. Not everyone agrees on whether resignation letters are necessary when nurses and other employees resign. Use a formal business format for the actual letter itself. Notify your manager in person before you submit your formal resignation letter. Nursing RN Resignation Letter Format ; Heading.