Learn how to write an immediate resignation letter with our comprehensive guide, including tips, examples, and a customizable template. Download Pennsylvania Immediate Letter Of Resignation template, modify and send for signing using BoloForms Signature.How to write a resignation letter that's effective immediately? To help you draft your resignation letter like the example above, here's a checklist of what to include: What to include in a resignation letter. At the beginning of your letter, consider immediately describing your intention to resign. "I received your request that I submit my resignation in writing. It is with regret that I have to resign my position as a nurse practitioner in the cardiac unit at UPMC East immediately. I hope this letter finds you well. Please accept this letter as my formal resignation. Today will be my last day of work.