As Johnson says, employees often find themselves in three stages within a job or career they like: 1. In this article, we will discuss how to write a resignation letter as a nurse and provide examples and tips.One of the main benefits of moving to a PRN role is the flexibility that PRN shifts give nurses. Even if you hate your job and can't wait to start your new job, it can be difficult to resign diplomatically and tactfully. If so, resigning can feel daunting, regardless of why you're leaving. A resignation letter is used to resign from a professional position. Nurses transitioning to a new role require a formal resignation letter. 2. Healthcare professionals who need to document their departure professionally. 3. The best way to leave a job is with grace. Nursing resignation letters should be short, to the point, and professional.